It's been a sad state of affairs for years on the corner of Seventh Avenue and Third Street, as one restaurant after another has tried to give it a go and failed. The most recent occupant of the space, Casa Ventura, opened with much hoopla and generally good reviews a little over a year ago, and even though it was run by well-intentioned locals, it's been closed more often than not lately, and has been placed on the market for a monthly rent of $9,500 (the listing actually uses photos that I took during their opening party and included in the article linked to above). It also mentions that it's back on the market after a previous deal fell through.
Several of Casa Ventura's owners opened Loli's Taqueria just about a month ago, and that space is already on the market as well. Even though it was generally well-liked and inexpensive, the off-the-main-drag location of Sixth Avenue and 7th Street didn't do it any favors, and it's also only been open very sporadically lately. It's on the market for a rent of about $4,000 per month.
While there's no such thing as a "cursed" space, it's certainly been incredibly challenging to find a winner for either of these two storefronts.